Fast, ligand- and solvent-free copper-catalyzed click reactions in a ball mill.
نویسندگان
چکیده
A new, ligand- and solvent-free method for the Huisgen 1,3-dipolar cycloaddition (click reaction) was developed using a planetary ball mill. Besides various alkynes and azides, a propargyl functionalized polymer was converted by mill clicking. Moreover, it was possible to carry out a click polymerization in a ball mill.
منابع مشابه
Solvent-free copper-catalyzed azide-alkyne cycloaddition under mechanochemical activation.
The ball-mill-based mechanochemical activation of metallic copper powder facilitates solvent-free alkyne-azide click reactions (CuAAC). All parameters that affect reaction rate (i.e., milling time, revolutions/min, size and milling ball number) have been optimized. This new, efficient, facile and eco-friendly procedure has been tested on a number of different substrates and in all cases afforde...
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ورودعنوان ژورنال:
- Chemical communications
دوره 47 15 شماره
صفحات -
تاریخ انتشار 2011